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Invitrogen
MMP19 Polyclonal Antibody
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MMP19 Antibody (PA1-24424) in IHC (P)
Immunohistochemistry (Paraffin) analysis of MMP19 in human colorectal cancer tissue and human small intestine tissue using MMP19 Polyclonal Antibody (Product # PA1-24424) at a dilution of 1:100. Antigen retrieval using citrate pH 6.0 solution at 96 degree C for 15 min.utes in a pressure cooker.
产品信息
PA1-24424
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region of human MMP-19.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Recommended positive controls: HepG2.
Predicted reactivity: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 79%; Mouse: 86%; Rabbit: 93%; Rat: 93%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
