Invitrogen

MORF Polyclonal Antibody

Name: MORF Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-37101

1 篇参考文献

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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MORF Antibody (PA5-37101) in WB

Western blot analysis of MORF/MYST4 using MORF/MYST4 polyclonal antibody (Product # PA5-37101) at a dilution of 1:500. Lane 1: HEK293T whole cell lysate, Lane 2: Raw264.7 whole cell lysate, Lane 3: NIH-3T3 whole cell lysate.

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产品信息

PA5-37101

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to residues in human KAT6B

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2553909

产品详细信息

This antibody detects endogenous protein at a molecular weight of 231 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. Tip60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Histone acetyltransferase KAT6B; histone acetyltransferase MORF; Histone acetyltransferase MOZ2; histone acetyltransferase MYST4; histone acetyltransferase querkopf; K(lysine) acetyltransferase 6B; monocytic leukemia; Monocytic leukemia zinc finger protein-related factor; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ-related factor; MYST histone acetyltransferase (monocytic leukemia) 4; MYST histone acetyltransferase monocytic leukemia 4; MYST-4; Protein querkopf; SAS2; TIP60 protein 4

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基因别名: AI507552; B130044K16Rik; GTPTS; KAT6B; KIAA0383; mKIAA0383; MORF; MOZ2; MYST-4; MYST4; qkf; querkopf; ZC2HC6B

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UniProt ID: (Human) Q8WYB5, (Mouse) Q8BRB7

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Entrez Gene ID: (Human) 23522, (Mouse) 54169

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功能