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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Mas-related G-protein coupled receptor member B10; Mas-related G-protein coupled receptor member X2; MAS-related GPR, member B10
基因别名: G370024M05Rik; MrgB10; Mrgprb10; MRGPRX2; MRGX2
UniProt ID: (Mouse) Q3UG50
Entrez Gene ID: (Mouse) 243978