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产品信息
MA1-35687
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
M6II-31
抗原
ABCC6 aa 764-964
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
tissue culture supernatant with 0.7% BSA
内含物
0.1% sodium azide
保存条件
4° C
运输条件
Wet ice
RRID
AB_2219646
产品详细信息
M6II-31 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-31 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-31 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
靶标信息
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Anthracycline resistance-associated protein; ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; MOAT-E; Multi-specific organic anion transporter E; Multidrug resistance-associated protein 6
基因别名: ABC34; ABCC6; ARA; EST349056; GACI2; MLP1; MOAT-E; MOATE; MRP6; PXE; PXE1; URG7
UniProt ID: (Human) O95255
Entrez Gene ID: (Human) 368
