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Product Details
PA5-42851
产品规格
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human MRPS12
Conjugate
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2610370
Product Specific Information
Peptide sequence: LVPRLWATCS MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK
Sequence homology: Cow: 86%; Dog: 91%; Guinea Pig: 86%; Horse: 79%; Human: 100%; Rat: 86%
Target Information
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: 28S ribosomal protein S12, mitochondrial; Mitochondrial small ribosomal subunit protein uS12m; MRP-S12; MT-RPS12; S12mt
Gene Aliases: MPR-S12; MRPS12; MT-RPS12; RPMS12; RPS12; RPSM12
UniProt ID: (Human) O15235
Entrez Gene ID: (Human) 6183
Molecular Function:
ribosomal protein
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