Immunogen sequence: PQLKGVVLCT FTRKPKKPNS ANRKCCRVRL STGREAVCFI PGEGHTLQEH QIVLVEG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
蛋白别名: 28S ribosomal protein S12, mitochondrial; Mitochondrial small ribosomal subunit protein uS12m; MRP-S12; MT-RPS12; S12mt
基因别名: MPR-S12; MRPS12; MT-RPS12; RPMS12; RPS12; RPSM12
UniProt ID: (Human) O15235
Entrez Gene ID: (Human) 6183
分子生物学功能: ribosomal protein