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Invitrogen
MRVI1 Polyclonal Antibody
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产品信息
PA5-32111
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human MRVI1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: MCF-7.
Predicted reactivity: Rat (86%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IP3R-associated cGMP kinase substrate; JAW1-related protein MRVI1; Protein MRVI1
基因别名: IRAG; IRAG1; JAW1L; MRVI1
UniProt ID: (Human) Q9Y6F6
Entrez Gene ID: (Human) 10335
