Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
This antibody detects endogenous protein at a molecular weight of 39 kDa.
Purity is >95% by SDS-PAGE.
MT-ND2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: NADH dehydrogenase subunit 2; NADH-ubiquinone oxidoreductase chain 2
基因别名: MT-ND2; MTND2; NADH2; ND2
UniProt ID: (Human) P03891, (Rat) P11662, (Mouse) P03893
Entrez Gene ID: (Human) 4536, (Rat) 26194, (Mouse) 17717
