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Rockland
MTBP Monoclonal Antibody (PHL-1)
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产品信息
500-301-875
产品规格
种属反应
Chimpanzee,
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
PHL-1
抗原
recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
0.02M potassium phosphate/ascites, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is directed against human MTBP protein. The product was produced from clarified mouse ascetic fluid. A BLAST analysis was used to suggest reactivity with this protein from human (100% homology) and chimpanzee. Cross reactivity with MTBP protein from mouse (77% homology) and chicken (79% homology) is unlikely due to the relatively low number of positive residues and high number of gaps within this sequence. Cross reactivity with MTBP homologues from other sources has not been determined.
靶标信息
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2-binding protein; MGC5370; MGC71221
基因别名: MDM2BP; MTBP
UniProt ID: (Human) Q96DY7
Entrez Gene ID: (Human) 27085
