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Proteintech
MTHFD1 Polyclonal Antibody
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产品信息
10794-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MTHFD1 Fusion Protein Ag1225 (536-935 aa encoded by BC009806)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TNDRFLRKI TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS KKGEPVSAED LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH GNSSIIADQI ALKLVGPEGF VVTEAGFGAD IGMEKFFNIK CRYSGLCPHV VVLVATVRAL KMHGGGPTVT AGLPLPKAYI QENLELVEKG FSNLKKQIEN ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK CTHWAEGGKG ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS VGAGFLYPLV GTMSTMPGLP TRPCFYDIDL DPETEQVNGL F (536-935 aa encoded by BC009806)
靶标信息
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C1-tetrahydrofolate synthase; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; Epididymis secretory sperm binding protein; methenyltetrahydrofolate; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
基因别名: Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1
UniProt ID: (Human) P11586, (Mouse) Q922D8
Entrez Gene ID: (Human) 4522, (Mouse) 108156
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
protein binding
ATP binding
nucleotide binding
catalytic activity
oxidoreductase activity
hydrolase activity
ligase activity
histidine biosynthetic process
neutrophil homeostasis
neural tube closure
purine nucleotide biosynthetic process
methionine metabolic process
one-carbon metabolic process
heart development
serine family amino acid metabolic process
serine family amino acid biosynthetic process
methionine biosynthetic process
10-formyltetrahydrofolate biosynthetic process
transsulfuration
tetrahydrofolate interconversion
folic acid metabolic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
oxidation-reduction process
somite development
metabolic process
cellular amino acid biosynthetic process
folic acid-containing compound biosynthetic process
