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Invitrogen
MTHFD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-117147
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.16 mg/mL
规格
116 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Raji, LO2, Mouse brain, Mouse kidney, Rat spinal cord
Immunogen sequence: MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP EKDVDGLTSI NAGKLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY VPDDKKPNGR KVVGDVAYDE AKERASFITP
靶标信息
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-1-tetrahydrofolate synthase, cytoplasmic; C1-tetrahydrofolate synthase; C1-THF synthase; Epididymis secretory sperm binding protein; methenyltetrahydrofolate; methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
基因别名: Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1
UniProt ID: (Mouse) Q922D8, (Rat) P27653
Entrez Gene ID: (Mouse) 108156, (Rat) 64300
nucleotide binding
catalytic activity
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
ATP binding
oxidoreductase activity
hydrolase activity
ligase activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
histidine biosynthetic process
neutrophil homeostasis
neural tube closure
purine nucleotide biosynthetic process
methionine metabolic process
one-carbon metabolic process
heart development
metabolic process
cellular amino acid biosynthetic process
serine family amino acid metabolic process
serine family amino acid biosynthetic process
methionine biosynthetic process
10-formyltetrahydrofolate biosynthetic process
folic acid-containing compound biosynthetic process
transsulfuration
tetrahydrofolate interconversion
oxidation-reduction process
somite development
nucleotide metabolic process
tetrahydrofolate metabolic process
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