Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1-3 µg/mL | - |
免疫组化(石蜡) (IHC (P)) |
10 µg/mL | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Goat / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide sequence (SSPSQMMPHVQTHF) corresponding to the C-terminus amino acids of MTM1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
TBS, pH 7.3, with 0.5% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_11002306 |
This antibody is predicted to react with bovine, canine and mouse based on sequence homology.
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
基因别名: AF073996; CG2; CNM; mKIAA4176; Mtm; MTM1; MTMX; XLMTM
UniProt ID: (Human) Q13496, (Mouse) Q9Z2C5
Entrez Gene ID: (Human) 4534, (Mouse) 17772
分子生物学功能:
phosphatase