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Proteintech
MTMR2 Polyclonal Antibody
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产品信息
14372-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MTMR2 Fusion Protein Ag5745 (294-643 aa encoded by BC052990)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KRSKEDEKY LQAIMDSNAQ SHKIFIFDAR PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD RTAQLTSLAM LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC NSEQQRGKEN LPKRTVSLWS YINSQLEDFT NPLYGSYSNH VLYPVASMRH LELWVGYYIR WNPRMKPQEP IHNRYKELLA KRAELQKKVE ELQREISNRS TSSSERASSP AQCVTPVQTV V (294-643 aa encoded by BC052990)
靶标信息
This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Myotubularin-related protein 2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; phosphatidylinositol-3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; phosphoinositide-3-phosphatase
基因别名: 6030445P13Rik; CMT4B; CMT4B1; KIAA1073; MTMR2
UniProt ID: (Human) Q13614, (Mouse) Q9Z2D1
Entrez Gene ID: (Human) 8898, (Mouse) 77116, (Rat) 315422
phosphatidylinositol-3-phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/serine/threonine phosphatase activity
protein homodimerization activity
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
hydrolase activity
phosphatase activity
phosphatidylinositol phosphate phosphatase activity
phosphatase
negative regulation of receptor internalization
protein dephosphorylation
phosphatidylinositol biosynthetic process
negative regulation of myelination
myelin assembly
peptidyl-tyrosine dephosphorylation
negative regulation of endocytosis
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
neuron development
protein tetramerization
negative regulation of excitatory postsynaptic potential
dendritic spine maintenance
positive regulation of early endosome to late endosome transport
negative regulation of receptor catabolic process
lipid metabolic process
dephosphorylation
phosphatidylinositol metabolic process
