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Proteintech
MTMR2 Monoclonal Antibody (1B11B7), CoraLite® Plus 488
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MTMR2 Antibody (CL488-67312) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human MTMR2 (CL488-67312, Clone:1B11B7) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
产品信息
CL488-67312
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1B11B7
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: KRSKEDEKYL QAIMDSNAQS HKIFIFDARP SVNAVANKAK GGGYESEDAY QNAELVFLDI HNIHVMRESL RKLKEIVYPN IEETHWLSNL ESTHWLEHIK LILAGALRIA DKVESGKTSV VVHCSDGWDR TAQLTSLAML MLDGYYRTIR GFEVLVEKEW LSFGHRFQLR VGHGDKNHAD ADRSPVFLQF IDCVWQMTRQ FPTAFEFNEY FLITILDHLY SCLFGTFLCN SEQQRGKENL PKRTVSLWSY INSQLEDFTN PLYGSYSNHV LYPVASMRHL ELWVGYYIRW NPRMKPQEPI HNRYKELLAK RAELQKKVEE LQREISNRST SSSERASSPA QCVTPVQTVV
靶标信息
This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Myotubularin-related protein 2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; phosphatidylinositol-3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; phosphoinositide-3-phosphatase
基因别名: CMT4B; CMT4B1; KIAA1073; MTMR2
UniProt ID: (Human) Q13614
Entrez Gene ID: (Human) 8898
negative regulation of receptor internalization
protein dephosphorylation
phosphatidylinositol biosynthetic process
negative regulation of myelination
myelin assembly
peptidyl-tyrosine dephosphorylation
negative regulation of endocytosis
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
neuron development
protein tetramerization
negative regulation of excitatory postsynaptic potential
dendritic spine maintenance
positive regulation of early endosome to late endosome transport
negative regulation of receptor catabolic process
