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Positive test controls include: 293T, HepG2, Mouse brain, Mouse liver. The target is usually found in the following locations: Cytoplasm, Membrane, Peripheral membrane protein.
Immunogen sequence: GEATPRRLLS YGCCSKRPNS KQMRATGPCF GGQWAQREGV KSPVCSSHSN GHCTGPGGKN QMWLSSHPKQ VSSTKPVPLN CPSPVPPLYL DDDGLPFPTD VIQHRLRQIE AGYKQEVEQL RRQVRELQMR LDIRHCCAPP AEPPMDYEDD FTCLKESDGS DTEDFGSDHS EDCLSEASWE PVDKKETEVT RWVPDHMASH CYNCDCEFWL AKRRHHCRNC GNVFCAGCCH LKLPIPDQQL YDPVLVCNSC YEHIQVSRAR ELMSQQLKKP IATASS
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1, 195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp781E194; FYVE domain-containing dual specificity protein phosphatase 2; FYVE zinc finger phosphatase; FYVE-DSP2; MGC163449; MGC163451; MTMR7; Myotubularin-related protein 4; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 11; zinc finger, FYVE domain containing 11
基因别名: AA596759; ESTM44; FYVE-DSP2; KIAA0647; mKIAA0647; MTMR4; ZFYVE11
UniProt ID: (Human) Q9NYA4, (Mouse) Q91XS1
Entrez Gene ID: (Human) 9110, (Mouse) 170749