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MYBBP1A Antibody (PA5-96287) in WB
Western blot analysis of MYBBP1A in extracts of various cell lines. Samples were incubated with MYBBP1A Polyclonal antibody (Product # PA5-96287) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-96287
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A.
Conjugate
Unconjugated
形式
Liquid
浓度
0.60 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2808089
Product Specific Information
Immunogen sequence: DLTVLLGVLQ GQQQSLQQGA HSTGSSRLHD LYWQAMKTLG VQRPKLEKKD AKEIPSATQS PISKKRKKKG FLPETKKRKK RKSEDGTPAE DGTPAATGGS QPPSMGRKKR NRTKAKVPAQ ANGTPTTKSP APGAPTRSPS TPAKSPKLQK KNQKPSQVNG APGSPTEPAG QKQHQKALPK KGVLGKSPLS ALARKKARLS LVIRSPSLLQ SGAKKKAQVR KAGKP; Positive Samples: HeLa, SW620, MCF7, Mouse liver, Rat liver; Cellular Location: Cytoplasm, Nucleus, nucleolus
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: MYB binding protein 1a; MYB binding protein (P160) 1a; Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160; p53-activated protein-2; PAR interacting protein; PAR-interacting protein; PIP
Gene Aliases: AL024407; AU019902; DBP; MYBBP1A; P160; p160MBP; p67MBP; PAP2
UniProt ID: (Human) Q9BQG0, (Rat) O35821, (Mouse) Q7TPV4
Entrez Gene ID: (Human) 10514, (Rat) 60571, (Mouse) 18432
Molecular Function:
chromatin/chromatin-binding, or -regulatory protein
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of cell cycle arrest
DNA biosynthetic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
rhythmic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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