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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:2,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:50 - 1:200 | - |
免疫细胞化学 (ICC/IF) |
1:50-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.58 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.3, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2808089 |
Immunogen sequence: DLTVLLGVLQ GQQQSLQQGA HSTGSSRLHD LYWQAMKTLG VQRPKLEKKD AKEIPSATQS PISKKRKKKG FLPETKKRKK RKSEDGTPAE DGTPAATGGS QPPSMGRKKR NRTKAKVPAQ ANGTPTTKSP APGAPTRSPS TPAKSPKLQK KNQKPSQVNG APGSPTEPAG QKQHQKALPK KGVLGKSPLS ALARKKARLS LVIRSPSLLQ SGAKKKAQVR KAGKP; Positive Samples: HeLa, SW620, MCF7, Mouse liver, Rat liver; Cellular Location: Cytoplasm, Nucleus, nucleolus
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MYB binding protein 1a; MYB binding protein (P160) 1a; Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160; p53-activated protein-2; PAR interacting protein; PAR-interacting protein; PIP
基因别名: AL024407; AU019902; DBP; MYBBP1A; P160; p160MBP; p67MBP; PAP2
UniProt ID: (Human) Q9BQG0, (Rat) O35821, (Mouse) Q7TPV4
Entrez Gene ID: (Human) 10514, (Rat) 60571, (Mouse) 18432
分子生物学功能:
chromatin/chromatin-binding, or -regulatory protein
