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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
1:1,000-1:2,500 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein corresponding to Human MYSM1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.3 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2644401 |
Immunogen sequence: KQDETLSSSE ITLWTEKQSN GDKKSIELND QKFNELIKNC NKHDGRGIIV DARQLPSPEP CEIQKNLNDN EMLFHSCQMV EESHEEEELK
Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 44%.
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2A-DUB; Deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1
基因别名: 2A-DUB; 2ADUB; KIAA1915; MYSM1
UniProt ID: (Human) Q5VVJ2
Entrez Gene ID: (Human) 114803
分子生物学功能:
chromatin/chromatin-binding, or -regulatory protein
