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Invitrogen
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Immunogen sequence: VNCIGRIHTY LELIGAINFG CEQAVYNRPQ TVDKVRIRDR KDAVEAYQLA QRLQSMRTRR RRVRDPWGNW CDAKDLEGQT FEHLS
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2A-DUB; Deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1
基因别名: 2A-DUB; 2ADUB; KIAA1915; MYSM1
UniProt ID: (Human) Q5VVJ2
Entrez Gene ID: (Human) 114803