Invitrogen

Menin Polyclonal Antibody

查看其他20个Menin抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-85330

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫沉淀 (IP)

1:100-1:500
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human Menin. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.03 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792472

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (97%), Rat (97%), Dog (99%), Bovine (98%).

Positive Control: Jurkat, Raji.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Menin; multiple endocrine neoplasia I

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基因别名: MEAI; MEN1; SCG2

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UniProt ID: (Human) O00255

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Entrez Gene ID: (Human) 4221

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功能
four-way junction DNA binding Y-form DNA binding chromatin binding double-stranded DNA binding protein binding histone-lysine N-methyltransferase activity protein binding, bridging transcription regulatory region DNA binding protein N-terminus binding R-SMAD binding
参与通路
negative regulation of transcription from RNA polymerase II promoter MAPK cascade mitotic cell cycle negative regulation of protein phosphorylation osteoblast development type B pancreatic cell differentiation DNA repair transcription, DNA-templated cellular response to DNA damage stimulus brain development negative regulation of cell proliferation response to UV response to gamma radiation negative regulation of cell-substrate adhesion positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein binding regulation of activin receptor signaling pathway histone lysine methylation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade decidualization negative regulation of epithelial cell proliferation negative regulation of telomerase activity regulation of type B pancreatic cell proliferation cellular response to glucose stimulus cellular response to peptide hormone stimulus response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition beta-catenin-TCF complex assembly
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