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Invitrogen
Metapneumovirus Fusion glycoprotein F0 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (ABS0704)
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产品信息
MA562815
产品规格
种属反应
Virus
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ABS0704
抗原
Recombinant HMPV F protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Metapneumovirus Fusion glycoprotein F0 (hMPV F0) is a precursor form of the fusion (F) protein found in Human Metapneumovirus (hMPV) which is an enveloped virus responsible for respiratory tract infections particularly in children elderly and immunocompromised individuals. The F protein plays a critical role in viral entry as it facilitates the merger of the viral envelope with host cell membranes enabling the viral genome to access the host's cellular machinery. Initially synthesized as a precursor F0 polypeptide it undergoes cleavage to form the active F1 and F2 subunits with F1 being responsible for the actual fusion activity. This cleavage and activation of the F protein is essential for the virus's infectivity and pathogenicity. The structure of the F protein characterized by its alpha-helical and coiled-coil domains is a target for neutralizing antibodies and antiviral drugs aiming to block the fusion process thereby preventing infection. Research into the Metapneumovirus Fusion glycoprotein F0 provides insights into vaccine development and therapeutic interventions aimed at mitigating the impact of hMPV infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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