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Invitrogen
Mitochondria Membrane Integrity Antibody Cocktail
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产品信息
45-7799
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ Ig
分类
Cocktail
类型
Antibody
克隆号
Cocktail
偶联物
形式
Liquid
浓度
2.37 mg/mL
规格
255 µg
纯化类型
IgG fraction
保存液
HEPES buffered saline
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Mitochondria Membrane Integrity cocktail of monoclonal antibodies specific to human, bovine, mouse, rat mitochondria membranes. This antibody is validated for use in Western Blot, and can be used to assess mitochondrial membrane integrity during and after purification.
Contains:
50 µg of Porin clone #2B12AF12 - Human VDAC1. Concentration 2 µg/mL.
50 µg of Cyclophilin D clone #E11AE12BD4 - Rat CypD/PPIF. Concentration 2 µg/mL.
50 µg of C-III-Core 1 clone # 16D10AD9AH5 - Bovine Heart Complex II/III. Concentration 2 µg/mL.
5 µg of Cytochrome C clone #37BA11 - Human Cytochrome c. Concentration 0.1 µg/mL.
100 µg of C-V-a clone #7H10BD4F9 - Bovine Complex V. Concentration 4 µg/mL.
This antibody cocktail (2.37 mg/mL) should be diluted to a final working concentration of 10.2 µg/mL for use in Western blot applications.
靶标信息
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC contitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 16D10AD9AH5; 20B12AF2; 37BA11; 7H10BD4F9; BR1-VDAC; Brain-derived voltage-dependent anion channel 1; Complex III subunit 4; Complex III subunit IV; CYC1; cyclophilin 3; Cyclophilin D; Cyclophilin F; CYCS; CyP-D; CyP-M; Cytochrome b-c1 complex subunit 4; Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; Cytochrome c-1; cytochrome c1; Cytochrome c1, heme protein, mitochondrial; E11AE12BD4; Mitochondrial cyclophilin; mitochondrial Cyclophilin D; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F; Plasmalemmal porin; Porin 31HL; Porin 31HM; PPIase F; Rotamase F; rVDAC1; sperm binding protein 1a; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit; unnamed protein product; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
基因别名: 2610002H19Rik; AA408921; AL033343; AW457192; CYC; CYC1; CYCS; CYCSA; CyP-D; CyP-F; CyP-M; CYP3; CypD; cytc; HCS; MC3DN6; PORIN; PPIase; PPIF; THC4; UQCR4; VDAC; VDAC-1; VDAC1; Vdac5
heme binding
metal ion binding
protein binding
ubiquinol-cytochrome-c reductase activity
electron carrier activity
molecular_function
iron ion binding
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
lipid binding
peptidyl-prolyl cis-trans isomerase activity
cyclosporin A binding
isomerase activity
peptide binding
nucleotide binding
voltage-gated anion channel activity
porin activity
voltage-gated ion channel activity
ATP binding
oxysterol binding
cholesterol binding
protein kinase binding
phosphatidylcholine binding
identical protein binding
ion channel binding
ceramide binding
anion channel activity
protein complex binding
voltage-gated ion channel
chaperone
mitochondrial electron transport, ubiquinol to cytochrome c
response to glucagon
cellular respiration
hydrogen ion transmembrane transport
mitochondrial electron transport, cytochrome c to oxygen
apoptotic process
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
execution phase of apoptosis
transport
oxidation-reduction process
apoptotic DNA fragmentation
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
hydrogen peroxide metabolic process
ATP synthesis coupled electron transport
response to ischemia
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
positive regulation of cellular respiration
protein folding
mitochondrion organization
apoptotic mitochondrial changes
regulation of proton-transporting ATPase activity, rotational mechanism
programmed cell death
negative regulation of apoptotic process
regulation of mitochondrial membrane permeability
mitochondrial depolarization
muscle structure development
necroptotic process
cellular response to hydrogen peroxide
cellular response to arsenic-containing substance
cellular response to calcium ion
negative regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation
skeletal muscle fiber differentiation
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
mitochondrial outer membrane permeabilization involved in programmed cell death
negative regulation of intrinsic apoptotic signaling pathway
protein peptidyl-prolyl isomerization
negative regulation of ATPase activity
positive regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation uncoupler activity
regulation of necrotic cell death
regulation of apoptotic process
anion transport
inorganic anion transport
anion transmembrane transport
behavioral fear response
ion transport
lipid transport
chemical synaptic transmission
neuron-neuron synaptic transmission
learning
epithelial cell differentiation
calcium ion transmembrane import into mitochondrion
positive regulation of apoptotic process
transmembrane transport
negative regulation of calcium import into the mitochondrion
regulation of mitophagy
regulation of mitophagy
positive regulation of type 2 mitophagy
mitochondrial transmembrane transport
negative regulation of reactive oxygen species metabolic process
mitochondrial calcium ion transport
regulation of anion transport
regulation of anion transmembrane transport
ion transmembrane transport
regulation of ion transmembrane transport
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