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产品信息
PEP-0019
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Mouse |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 18 amino acids near the center of mouse CAD.
PEP-0019 can be used as a blocking peptide with polyclonal antibody PA5-19891.
靶标信息
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aspartate carbamoyltransferase; CAD protein; Dihydroorotase; Glutamine-dependent carbamoyl-phosphate synthase
基因别名: 2410008J01Rik; AU018859; Cad; Cpad
UniProt ID: (Mouse) B2RQC6
Entrez Gene ID: (Mouse) 69719
urea cycle
'de novo' pyrimidine nucleobase biosynthetic process
pyrimidine nucleotide biosynthetic process
UTP biosynthetic process
cellular amino acid metabolic process
arginine biosynthetic process
glutamine metabolic process
nitrogen compound metabolic process
metabolic process
drug metabolic process
peptidyl-threonine phosphorylation
protein autophosphorylation
nucleotide binding
UTP binding
catalytic activity
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
protein kinase activity
ATP binding
zinc ion binding
amino acid binding
transferase activity
carboxyl- or carbamoyltransferase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ligase activity
enzyme binding
identical protein binding
metal ion binding
