Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
产品规格 | |
---|---|
种属反应 |
Mouse |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.5 mg/mL |
纯化类型 |
purified |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
PEP-181 is a 12 amino acid synthetic peptide whose sequence is derived from mouse PPAR alpha protein with serine 12 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: I (8)-C-P-L- (pS)-P-L-E-A-D-D-L (19)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse phospho-PPAR alpha (Ser12), catalog # PA1-820. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferator; peroxisome proliferator activated receptor; Peroxisome proliferator-activated receptor alpha; PPAR-alpha
基因别名: 4933429D07Rik; AW742785; Nr1c1; Ppar; PPAR-alpha; Ppara; PPARalpha
UniProt ID: (Mouse) P23204
Entrez Gene ID: (Mouse) 19013
分子生物学功能:
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator