Invitrogen

Mouse/Rat TRPM4 Synthetic Peptide

产品信息

GST00013P

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-

产品规格
种属反应	Mouse, Rat
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Lyophilized
纯化类型	purified
内含物	no preservative
保存条件	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

产品详细信息

GST00013P is the immunizing peptide for the antibody to rat and mouse TRPM4 Melastatin-like 2 (OSR00088W & OST00027W).

GST00013P may be used as a control in various immunology applications.

Reconstitute with PBS or distilled water.

靶标信息

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Calcium-activated non-selective cation channel 1; H LTrpC-4; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; melastatin like 2 protein; Melastatin-like 2; MLS2s; Transient receptor potential cation channel subfamily M member 4; transient receptor potential ion channel melastatin subgroup member 4

基因别名: 1110030C19Rik; AW047689; LTrpC-4; LTRPC4; Mls2s; Trpm4; TRPM4B

UniProt ID: (Mouse) Q7TN37, (Rat) Q9ESQ5

Entrez Gene ID: (Mouse) 68667, (Rat) 171143

分子生物学功能: ion channel transporter