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产品信息
PEP-0196
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Mouse |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 15 amino acids near the carboxy terminus of mouse SIGIRR.
PEP-0196 can be used as a blocking peptide with polyclonal antibody PA5-20078.
靶标信息
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC110992; single Ig IL-1 receptor related protein; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8
基因别名: AI256711; Sigirr; TIR8
UniProt ID: (Mouse) Q9JLZ8
Entrez Gene ID: (Mouse) 24058
分子生物学功能:
transmembrane signal receptor
