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产品信息
PEP-0710
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Mouse |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 16 amino acids near the carboxy terminus of mouse TRIM30
PEP-0710 can be used as a blocking peptide with polyclonal antibody PA5-20590.
靶标信息
TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kappa-B activation. The importance of TRIM30 in the attenuation or termination of NF-kappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30alpha may be a mechanism for modulating many types of immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; tripartite motif protein 30; tripartite motif-containing 30; Tripartite motif-containing protein 30; Tripartite motif-containing protein 30A
基因别名: Rpt-1; Rpt1; Trim30; Trim30a
UniProt ID: (Mouse) P15533
Entrez Gene ID: (Mouse) 20128
分子生物学功能:
ubiquitin-protein ligase
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
positive regulation of protein catabolic process
positive regulation of viral entry into host cell
protein autoubiquitination
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of reactive oxygen species metabolic process
