Invitrogen

Myeloperoxidase Monoclonal Antibody (4A4)

产品信息

MA1-20074

应用	建议稀释比	已发表文章
免疫印迹 (WB)	Assay-dependent	-
免疫组化 (IHC)	-	查看11篇已发表文章 11篇已发表文章
酶联免疫吸附实验 (ELISA)	Assay-dependent	-
亲和纯化 (AP)	Assay-dependent	-

产品规格
种属反应	Human
已发表种属	Human, Mouse, Rat
宿主/亚型	Mouse / IgG2b
分类	Monoclonal
类型	Antibody
克隆号	4A4
抗原	Purified, full length, native, human myeloperoxidase protein.
偶联物	Unconjugated
形式	Liquid
浓度	5.3 mg/mL
纯化类型	Protein A
保存液	PBS, pH 7.4
内含物	0.09% sodium azide
保存条件	4° C, do not freeze
RRID	AB_560236

产品详细信息

MA1-20074 detects Myeloperoxidase in human samples.

靶标信息

Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains with a molecular weight range of 59 - 64 kDa, and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and a theoretical pI of 9.2. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently, it was shown that myeloperoxidase participates in the initiation and progression of cardiovascular disease. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.

Arthritis and rheumatism

Appel H,Maier R,Bleil J,Hempfing A,Loddenkemper C,Schlichting U,Syrbe U,Sieper J

MA1-20074 was used in immunohistochemistry to study the presence and source of IL-12 and IL-23 in patients with ankylosing spondylitis

Sat Jun 01 00:00:00 EDT 2013

Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.

PloS one

Atkinson W,Forghani R,Wojtkiewicz GR,Pulli B,Iwamoto Y,Ueno T,Waterman P,Truelove J,Oklu R,Chen JW

MA1-20074 was used in immunohistochemistry to study whether chronic cerebrospinal venous insufficiency is a cause of multiple sclerosis using a murine model

Fri Aug 03 00:00:00 EDT 2012

Omega 3 fatty acids supplementation has an ameliorative effect in experimental ulcerative colitis despite increased colonic neutrophil infiltration.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

Varnalidis I,Ioannidis O,Karamanavi E,Ampas Z,Poutahidis T,Taitzoglou I,Paraskevas G,Botsios D

MA1-20074 was used in immunohistochemistry to study the efficacy of omega 3 fatty acids in the treatment of experimental ulcerative colitis

Sat Oct 01 00:00:00 EDT 2011

Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: a key role for superoxide anion.

European journal of pharmacology

El-Sayed NS,Mahran LG,Khattab MM

MA1-20074 was used in immunohistochemistry to study the mechanism by which a membrane-permeable radical scavenger protects against lipopolysaccharide-induced acute lung injury

Mon Aug 01 00:00:00 EDT 2011

Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kleijn A,Chen JW,Buhrman JS,Wojtkiewicz GR,Iwamoto Y,Lamfers ML,Stemmer-Rachamimov AO,Rabkin SD,Weissleder R,Martuza RL,Fulci G

MA1-20074 was used in immunohistochemistry to study the use of myeloperoxidase magnetic resonance imaging to differentiate inflammation from tumor/peritumor edema in gliomas

Fri Jul 01 00:00:00 EDT 2011

Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.

The Journal of surgical research

Belli S,Basaran O,Ozdemir BH,Türkoğlu S,Karabay G,Kut A,Karakayali H,Haberal M

MA1-20074 was used in immunohistochemistry to study the effect of simvastatin lung injury caused by burn and smoke inhalation

Sun May 15 00:00:00 EDT 2011

Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats.

Research in veterinary science

Zini E,Osto M,Moretti S,Franchini M,Kook PH,Lutz H,Guscetti F,Perren A,Hoelzle LE,Ackermann M,Lutz TA,Reusch CE

MA1-20074 was used in immunohistochemistry to study the effects of hyperglycaemia or hyperlipidaemia on the levels of serum amylase and neutrophils in the exocrine pancreas of cats

Sun Aug 01 00:00:00 EDT 2010

Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature.

The American journal of pathology

Marmon S,Hinchey J,Oh P,Cammer M,de Almeida CJ,Gunther L,Raine CS,Lisanti MP

MA1-20074 was used in immunohistochemistry to investigate the role of caveolin-1 in the guidence of neutrophil transmigration

Sun Feb 01 00:00:00 EST 2009

Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense.

American journal of physiology. Gastrointestinal and liver physiology

Kao JY,Rathinavelu S,Eaton KA,Bai L,Zavros Y,Takami M,Pierzchala A,Merchant JL

MA1-20074 was used in immunohistochemistry to study the role of Helicobacter pylori-secreted factors in the inhibition of dendritic cell IL-12 secretion

Sat Jul 01 00:00:00 EDT 2006

Mechanisms of c-reactive protein up-regulation in arterialized vein grafts.

Surgery

Gulkarov I,Pintucci G,Bohmann K,Saunders PC,Sullivan RF,Ferrari G,Mignatti P,Galloway AC

MA1-20074 was used in immunohistochemistry to study the molecular basis of c-reactive protein up-regulation in arterialized vein grafts

Wed Feb 01 00:00:00 EST 2006

Biliary intervention augments chemotactic reaction and aggravates cholestatic liver injury in rats.

The Journal of surgical research

Chuang JH,Chang NK,Huang CC,Lo SK,Wang HC,Chen CM,Wu CL,Chou MH,Lin TK

MA1-20074 was used in immunohistochemistry to study the mechanism by which biliary intervention stimulates chemotactic responses and worsens liver damage in a rat model of cholestatic liver injury

Sun Aug 01 00:00:00 EDT 2004

生物信息学

蛋白别名: 84 kDa myeloperoxidase; 89 kDa myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain

基因别名: MPO

UniProt ID: (Human) P05164

Entrez Gene ID: (Human) 4353

分子生物学功能: peroxidase

功能

response to yeast hypochlorous acid biosynthetic process respiratory burst involved in defense response defense response response to oxidative stress aging response to mechanical stimulus removal of superoxide radicals response to food response to lipopolysaccharide low-density lipoprotein particle remodeling hydrogen peroxide catabolic process negative regulation of apoptotic process negative regulation of growth of symbiont in host defense response to fungus oxidation-reduction process response to gold nanoparticle

参与通路

chromatin binding peroxidase activity heparin binding heme binding metal ion binding

Myeloperoxidase Monoclonal Antibody (4A4)

产品信息

MA1-20074

免疫印迹 (WB)

免疫组化 (IHC)

酶联免疫吸附实验 (ELISA)

亲和纯化 (AP)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Brands

Shopping Tools

eSolutions

Support

我们的公司

Your items have has been added!