应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
Assay-dependent | - |
免疫组化 (IHC) |
- | 查看11篇已发表文章 11篇已发表文章 |
酶联免疫吸附实验 (ELISA) |
Assay-dependent | - |
亲和纯化 (AP) |
Assay-dependent | - |
产品规格 | |
---|---|
种属反应 |
Human |
已发表种属 |
Human, Mouse, Rat |
宿主/亚型 |
Mouse / IgG2b |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
4A4 |
抗原 |
Purified, full length, native, human myeloperoxidase protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
5.3 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS, pH 7.4 |
内含物 |
0.09% sodium azide |
保存条件 |
4° C, do not freeze |
RRID |
AB_560236 |
MA1-20074 detects Myeloperoxidase in human samples.
Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains with a molecular weight range of 59 - 64 kDa, and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and a theoretical pI of 9.2. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently, it was shown that myeloperoxidase participates in the initiation and progression of cardiovascular disease. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 84 kDa myeloperoxidase; 89 kDa myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain
基因别名: MPO
UniProt ID: (Human) P05164
Entrez Gene ID: (Human) 4353
分子生物学功能:
peroxidase