AbboMax

Myosin Heavy Chain, Cardiac Monoclonal Antibody (9G11)

Name: Myosin Heavy Chain, Cardiac Monoclonal Antibody (9G11)
Brand: AbboMax
SKU: 603-820

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

Myosin Heavy Chain, Cardiac Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 2

Myosin Heavy Chain, Cardiac Antibody (603-820) in IHC (P)

Immunohistochemistry: Human Tonsil (FFPE) stained with Mouse anti-Myosin Heavy Chain (Cat# 603-820) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Myosin Heavy Chain, Cardiac Antibody in Western Blot (WB)

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产品信息

603-820

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-1 µg/mL

免疫组化（石蜡） (IHC (P))

2-10 µg/mL

产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

9G11

抗原

The recombinant protein of human myosin heavy chain recombinant protein

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS with proprietary stabilizer

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive control: Cardiac muscle

Cellular location: Cytoplasmic.

靶标信息

Cardiac Myosin Heavy Chain (MHC) is a crucial component of the contractile machinery in heart muscle cells. It primarily forms part of the thick filament in sarcomeres, the fundamental units of muscle contraction. The cardiac myosin heavy chain comes in two isoforms, alpha-MHC and beta-MHC, which are encoded by the MYH6 and MYH7 genes, respectively. The alpha-MHC isoform is predominant in the atria and is characterized by faster ATPase activity and contraction speed, whereas the beta-MHC isoform is predominant in the ventricles and is associated with greater endurance. Each myosin molecule consists of two heavy chains, two essential light chains (ELC), and two regulatory light chains (RLC). The heavy chains have distinct functional regions: the globular head, which binds to actin and hydrolyzes ATP to produce force, and the helical tail, which organizes into the thick filament backbone. Mutations in cardiac MHC can lead to various cardiomyopathies, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), both of which significantly affect the heart's functionality. These disorders underscore the importance of MHC in maintaining normal cardiac physiology and highlight its complex regulation and mechanotransduction capabilities.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: alpha cardiac MHC; alpha myosin; Antigen MLAA-21; beta myosin heavy chain; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain alpha isoform; cardiac myosin heavy chain beta isoform; cardiomyopathy, hypertrophic 1; MYH-beta/slow; MyHC-alpha; MyHC-beta; MyHC-slow; myopathy, distal 1; Myosin cardiac muscle beta chain; Myosin heavy chain 6; Myosin heavy chain 7; Myosin heavy chain 7B, cardiac muscle beta isoform; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain polypeptide 7 cardiac muscle fetal; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle alpha isoform; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, adult; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin heavy chain, polypeptide 7; myosin, heavy chain 7B, cardiac muscle, beta; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); myosin, heavy polypeptide 7, cardiac muscle, beta; myosin, heavy polypeptide 7B, cardiac muscle, beta; Myosin-6; Myosin-7; Myosin-7B; rhabdomyosarcoma antigen MU-RMS-40.7A; Slow A MYH14; type slow/beta myosin heavy chain; U937-associated antigen

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基因别名: A830009F23Rik; AA517445; alpha-MHC; ASD3; B-MHC; beta-MHC; CMD1EE; CMD1S; CMH1; CMH14; KIAA1512; MHC14; MPD1; MYH14; MYH6; MYH7; MYH7B; MYHC; Myhc-a; Myhc-b; MyHC-I; MYHCA; MYHCB; SPMD; SPMM; SSS3