FIGURE: 1 / 3
Peptide sequence: MAGENFATPF HGHVGRGAFS DVYEPAEDTF LLLNALEAAA AELAGVEICL
Sequence homology: Cow: 93%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 100%
Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.
Protein Aliases: HemK methyltransferase family member 2; Lysine N-methyltransferase 9; M-N6DNA MTase A; M.HsaHemK2P; Methylarsonite methyltransferase N6AMT1; Methyltransferase N6AMT1; n(6)-adenine-specific DNA methyltransferase 1; N6-DNA methyltransferase A; N6-DNA-methyltransferase; Protein N(5)-glutamine methyltransferase
Gene Aliases: 5830445C04Rik; C21orf127; HEMK2; KMT9; m.HsaHemK2P; MTQ2; N6AMT; N6AMT1; PRED28