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Invitrogen
NABP1 Polyclonal Antibody
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产品信息
PA5-65911
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EPNPDYRGQQN KGAQSEQKNN SMNSNMGTGT FGPVGNGVHT GPESREHQFS HAGRSNGRGL INPQLQGTAS NQTVMTTISN GRDPRRAFK
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 66%.
靶标信息
NABP1, also known as NABP1/Ssb2, is a single-stranded DNA-binding protein involved in genome maintenance and stability. The gene encoding NABP1 is regulated by RORgamma2, a retinoid-related orphan receptor critical for thymopoiesis. Research has demonstrated that NABP1 plays a compensatory role in thymic maturation, particularly in conditions where its homolog, SSB1, is knocked out. Despite SSB1's vital role in neonatal survival, NABP1 remains non-essential for thymic maturation and male fertility, indicating partial functional redundancy between these proteins. Furthermore, studies on the C-terminal regions of NABP1 have shown distinct roles in nucleic acid binding, contributing to DNA and RNA metabolism. These findings highlight NABP1's importance in genomic integrity and its complex interplay within cellular processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hSSB2; Nucleic acid-binding protein 1; oligonucleotide/oligosaccharide-binding fold containing 2A; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSS complex subunit B2; SOSS-B2
基因别名: NABP1; OBFC2A; SOSS-B2; SSB2
UniProt ID: (Human) Q96AH0
Entrez Gene ID: (Human) 64859
