Search Thermo Fisher Scientific
图: 1 / 1
Immunogen sequence: MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK; Positive Samples: SH-SY5Y, BT-474, HL-60, SW620, NIH/3T3, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cell membrane
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: amyloid beta precursor protein binding protein 1, 59kDa; Amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; Amyloid protein-binding protein 1; APP-BP1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8-activating enzyme E1 subunit; Proto-oncogene protein 1; protooncogene protein 1
基因别名: 59kDa; A-116A10.1; APPBP1; HPP1; NAE1; ula-1
UniProt ID: (Human) Q13564, (Mouse) Q8VBW6
Entrez Gene ID: (Human) 8883, (Mouse) 234664, (Rat) 84019
分子生物学功能: ubiquitin-protein ligase