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Invitrogen
NALCN (extracellular) Polyclonal Antibody
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NALCN (extracellular) Antibody (PA5-77736) in IHC
Immunohistochemistry analysis of NALCN (extracellular) in rat hypothalamus. A) Samples were probed with NALCN (extracellular) polyclonal antibody (Product # PA5-77736) and incubated with DAPI. B) Nuclei stained image. C) Merged image of Panels A and B.
产品信息
PA5-77736
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat Sodium leak channel non-selective protein
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
Nalcn is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Nalcn regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, Nalcn activity is enhanced/modulated by several GPCRs, is required for normal respiratory rhythm and neonatal survival, is involved in systemic osmoregulation by controlling the serum sodium concentration. Nalcn is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Further, Nalcn plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability. Diseases associated with NALCN include Congenital contractures of the limbs and face, Hypotonia, Developmental Delay and Hypotonia, Infantile Psychomotor Retardation And Characteristic Facies 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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