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NALP5 Antibody (PA5-97285) in WB
Western blot analysis of NALP5 in extracts of SKOV3 cells. Samples were incubated with NALP5 Polyclonal antibody (Product # PA5-97285) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 20s.
Product Details
PA5-97285
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 157-256 of human NLRP5.
Conjugate
Unconjugated
形式
Liquid
浓度
0.91 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2809087
Product Specific Information
Immunogen sequence: TMTDQGPSKE KVPGISQAVQ QDSATAAETK EQEISQAMEQ EGATAAETEE QEISQAMEQE GATAAETEEQ GHGGDTWDYK SHVMTKFAEE EDVRRSFENT; Positive Samples: SKOV3; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, nucleolus
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Mater protein; Mater protein homolog; Maternal Antigen that Embryos Require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; NLR family, pyrin domain containing 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5; Ooplasm-specific protein 1; OP1
Gene Aliases: CLR19.8; MATER; NALP5; NLRP5; Op1; PAN11; PYPAF8
UniProt ID: (Human) P59047, (Mouse) Q9R1M5
Entrez Gene ID: (Human) 126206, (Rat) 308325, (Mouse) 23968
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