FIGURE: 1 / 1
Immunogen sequence: TMTDQGPSKE KVPGISQAVQ QDSATAAETK EQEISQAMEQ EGATAAETEE QEISQAMEQE GATAAETEEQ GHGGDTWDYK SHVMTKFAEE EDVRRSFENT; Positive Samples: SKOV3; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, nucleolus
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Protein Aliases: Mater protein; Mater protein homolog; Maternal Antigen that Embryos Require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; NLR family, pyrin domain containing 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5; Ooplasm-specific protein 1; OP1
Gene Aliases: CLR19.8; MATER; NALP5; NLRP5; Op1; PAN11; PYPAF8