Search Thermo Fisher Scientific
Peptide sequence: KAIIDEFEQK LRACHTRGLD GIKELEIGQA GSQRAPSAKK PSTGSRYQPL
Sequence homology: Dog: 79%; Horse: 93%; Human: 100%; Pig: 92%; Rabbit: 92%
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: chromosome condensation related SMC associated protein 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Condensin complex subunit 1; hCAP-D2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; XCAP-D2 homolog
基因别名: CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; NCAPD2
UniProt ID: (Human) Q15021
Entrez Gene ID: (Human) 9918