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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.1-0.5 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
E. coli-derived human NCOA4 recombinant protein (Position: D22-A170). |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
500 µg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS with 4mg trehalose |
内含物 |
0.05mg sodium azide |
保存条件 |
-20°C |
RRID |
AB_2746834 |
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; Androgen receptor-associated protein of 70 kDa; NCoA-4; Nuclear receptor coactivator 4; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1
基因别名: ARA70; ELE1; NCOA4; PTC3; RFG
UniProt ID: (Human) Q13772
Entrez Gene ID: (Human) 8031, (Mouse) 27057, (Rat) 619385
分子生物学功能:
transcription cofactor
