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Invitrogen
NDP Monoclonal Antibody (343711)
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产品信息
MA5-61243
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
343711
抗原
E. coli-derived recombinant human Norrin, Lys25-Ser133
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
NDP (Norrie disease protein), also known as norrin, is a secreted signaling protein encoded by the NDP gene that activates the canonical Wnt/β-catenin pathway by binding the Frizzled-4 (FZD4)/LRP5 receptor complex. It plays an essential role in retinal vascular development, maintenance of the blood-retina barrier, and inner ear vascularization. Loss-of-function variants in NDP cause Norrie disease and can also contribute to familial exudative vitreoretinopathy (FEVR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NDP; NDP, norrin cystine knot growth factor; Norrie disease (pseudoglioma); norrie disease protein; norrie disease protein homolog; unnamed protein product; X-linked exudative vitreoretinopathy 2 protein
基因别名: EVR2; FEVR; ND; Ndph
UniProt ID: (Human) Q00604, (Mouse) P48744
Entrez Gene ID: (Human) 4693, (Mouse) 17986
vacuole organization
nervous system development
visual perception
Wnt signaling pathway
extracellular matrix-cell signaling
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
decidualization
Norrin signaling pathway
mitotic cell cycle
re-entry into mitotic cell cycle
action potential
angiogenesis
response to hypoxia
placenta development
blood vessel remodeling
lens development in camera-type eye
retinal pigment epithelium development
neural retina development
tricarboxylic acid cycle
transcription from RNA polymerase II promoter
protein phosphorylation
glycine metabolic process
L-serine metabolic process
protein targeting to lysosome
glutathione metabolic process
inflammatory response
transforming growth factor beta receptor signaling pathway
smoothened signaling pathway
protein localization
cell proliferation
regulation of signal transduction
gene expression
retina layer formation
microglia differentiation
dendrite development
protein ubiquitination
optic nerve development
neuron differentiation
retinal ganglion cell axon guidance
exploration behavior
endothelial cell differentiation
response to axon injury
neuron apoptotic process
positive regulation of protein kinase B signaling
retina development in camera-type eye
retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
retinal rod cell differentiation
establishment of blood-brain barrier
dendritic spine development
retina vasculature development in camera-type eye
retina vasculature morphogenesis in camera-type eye
retinal blood vessel morphogenesis
microglial cell proliferation
ubiquitin-dependent endocytosis
cellular response to hypoxia
retina blood vessel maintenance
cone retinal bipolar cell differentiation
establishment of blood-retinal barrier
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