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Proteintech
NEIL3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
11621-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NEIL3 Fusion Protein Ag2200 (257-605 aa encoded by BC025954)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.35 mg/mL
规格
52.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: CHCRITVCR FGDNNRMTYF CPHCQKENPQ HVDICKLPTR NTIISWTSSR VDHVMDSVAR KSEEHWTCVV CTLINKPSSK ACDACLTSRP IDSVLKSEEN STVFSHLMKY PCNTFGKPHT EVKINRKTAF GTTTLVLTDF SNKSSTLERK TKQNQILDEE FQNSPPASVC LNDIQHPSKK TTNDITQLSS KVNISPTISS ESKLFSPAHK KPKTAHYSSP ELKSCNPGYS NSELQINMTD GPRTLNPDSP RCSKHNRLCI LRVVRKDGEN KGRQFYACPL PREAQCGFFE WADLSFPFCN HGKRSTMKTV LKIGPNNGKN FFVCPLGKEK QCNFFQWAEN GPGIKIIPGC (257-605 aa encoded by BC025954)
靶标信息
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; Endonuclease VIII-like 3; FLJ10858; nei endonuclease VIII-like 3; Nei-like protein 3
基因别名: AI449477; BC034753; C85903; Neil3
UniProt ID: (Mouse) Q8K203
Entrez Gene ID: (Mouse) 234258
bubble DNA binding
purine-specific mismatch base pair DNA N-glycosylase activity
nucleic acid binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
uracil DNA N-glycosylase activity
zinc ion binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
metal ion binding
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA glycosylase
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