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OMA1-06116 detects both the phosphorylated and non-phosphorylated forms of the 200 kDa neurofilament from rat, guinea pig, rabbit, dog, hamster, chicken, mouse, cow, monkey, sheep, xenopus and human tissues.
OMA1-06116 has been successfully used in immunohistochemical (frozen & paraffin) and Western blot procedures. By Western blot, this antibody detects a single ~200 kDa protein representing both forms of the 200 kDa neurofilament from rat brain homogenate.
OMA1-06116 antigen is cytoskeletal preparation of calf brain tissue.
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 200 kDa neurofilament protein; heavy neurofilament protein; intermediate filament protein; NEF3; neurofilament; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; neurofilament, heavy polypeptide L homeolog; neurofilament-H; NF 200 kD; NF-H; NHC
基因别名: CMT2CC; I79_012512; KIAA0845; mKIAA0845; NEFH; NF-H; NF200; NFH; XELAEV_18007418mg
UniProt ID: (Human) P12036, (Mouse) P19246
Entrez Gene ID: (Dog) 442940, (Human) 4744, (Sheep) 101107472, (Chicken) 417020, (Rabbit) 100357177, (Chinese hamster) 100753127, (Guinea pig) 100716406, (Rat) 24587, (Mouse) 380684, (Western clawed frog) 100101753, (Xenopus) 108715402
