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Proteintech
NFE2 Polyclonal Antibody
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产品信息
11089-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NFE2 Fusion Protein Ag1570 (1-373 aa encoded by BC005044)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This is a rabbit polyclonal antibody raised against full-length NFE2 of human origin.
Immunogen sequence: MSPCPPQQS RNRVIQLSTS ELGEMELTWQ EIMSITELQG LNAPSEPSFE PQAPAPYLGP PPPTTYCPCS IHPDSGFPLP PPPYELPAST SHVPDPPYSY GNMAIPVSKP LSLSGLLSEP LQDPLALLDI GLPAGPPKPQ EDPESDSGLS LNYSDAESLE LEGTEAGRRR SEYVEMYPVE YPYSLMPNSL AHSNYTLPAA ETPLALEPSS GPVRAKPTAR GEAGSRDERR ALAMKIPFPT DKIVNLPVDD FNELLARYPL TESQLALVRD IRRRGKNKVA AQNCRKRKLE TIVQLERELE RLTNERERLL RARGEADRTL EVMRQQLTEL YRDIFQHLRD ESGNSYSPEE YALQQAADGT IFLVPRGTKM EATD (1-373 aa encoded by BC005044)
靶标信息
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Leucine zipper protein NF-E2; nuclear factor (erythroid-derived 2), 45kD; nuclear factor (erythroid-derived 2), 45kDa; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2; Transcription factor NF-E2 45 kDa subunit
基因别名: NF-E2; NFE2; p45
UniProt ID: (Human) Q16621
Entrez Gene ID: (Human) 4778
