Immunogen sequence: WNRRNDMGET LLHRACIEGQ LRRVQDLVRQ GHPLNPRDYC GWTPLHEACN YGHLEIVRFL LDHGAAVDDP GGQGCEGITP LHDALNCGHF EVAELLLERG ASVTLRTRK
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
蛋白别名: DNA repair protein; I-kappa-B-related protein; ikappaBR; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; tonsoku-like; Tonsoku-like protein
基因别名: IKBR; NFKBIL2; TONSL
UniProt ID: (Human) Q96HA7
Entrez Gene ID: (Human) 4796