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Proteintech
NFKBIZ Polyclonal Antibody
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产品信息
14014-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NFKBIZ Fusion Protein Ag5120 (369-718 aa encoded by BC060800)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: AHLHSFSMM PSSACEAMVG HEMASDSSNT SLPFSNMGNP MNTTQLGKSL FQWQVEQEES KLANISQDQF LSKDADGDTF LHIAVAQGRR ALSYVLARKM NALHMLDIKE HNGQSAFQVA VAANQHLIVQ DLVNIGAQVN TTDCWGRTPL HVCAEKGHSQ VLQAIQKGAV GSNQFVDLEA TNYDGLTPLH CAVIAHNAVV HELQRNQQPH SPEVQELLLK NKSLVDTIKC LIQMGAAVEA KDRKSGRTAL HLAAEEANLE LIRLFLELPS CLSFVNAKAY NGNTALHVAA SLQYRLTQLD AVRLLMRKGA DPSTRNLENE QPVHLVPDGP VGEQIRRILK GKSIQQRAPP Y (369-718 aa encoded by BC060800)
靶标信息
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ30225; FLJ34463; I-kappa-B-zeta; Ikappa B-zeta variant 3; IkappaB-zeta; ikappaBzeta; IkB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340
基因别名: AA408868; IKBZ; INAP; MAIL; NFKBIZ; RGD1310834
UniProt ID: (Human) Q9BYH8, (Mouse) Q9EST8
Entrez Gene ID: (Human) 64332, (Rat) 304005, (Mouse) 80859
