Invitrogen

NGF Receptor Polyclonal Antibody

View all (29) NGFR (CD271) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Tech Support

Product Details

PA5-96054

Applications
Tested Dilution
Publications

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

分类

Polyclonal

类型

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 330 to the C-terminus of human NGFR

Conjugate

Unconjugated

形式

Liquid

浓度

4.38 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2807856

Product Specific Information

Positive Samples: PC-3, SW480, PC-12, A375, A673, ES-2, MCF7, Mouse heart, Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Bioinformatics

Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 neurotrophin receptor; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16

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Gene Aliases: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NGFR; p75NTR; RNNGFRR; TNFRSF16

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UniProt ID: (Human) P08138, (Rat) P07174, (Mouse) Q9Z0W1

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Entrez Gene ID: (Human) 4804, (Rat) 24596, (Mouse) 18053

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Molecular Function: transmembrane signal receptor

Function(s)
intracellular protein transport activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response immune response axon guidance response to wounding negative regulation of neuron projection development sensory perception of pain membrane protein intracellular domain proteolysis positive regulation of myelination positive regulation of synaptic transmission, cholinergic response to lipopolysaccharide circadian regulation of gene expression tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress positive regulation of Rho protein signal transduction skeletal muscle cell differentiation regulation of cell proliferation glucose homeostasis regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process neurotrophin TRK receptor signaling pathway negative regulation of axonogenesis positive regulation of axonogenesis positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic apoptotic signaling pathway positive regulation of neuron death regulation of reactive oxygen species metabolic process regulation of glucose import in response to insulin stimulus apoptotic process signal transduction central nervous system development regulation of gene expression positive regulation of cell death programmed cell death detection of temperature stimulus nerve development hair follicle morphogenesis negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of odontogenesis of dentin-containing tooth skin development positive regulation of fibroblast proliferation negative regulation of hair follicle development negative regulation of cell death positive regulation of apoptotic signaling pathway multicellular organism development nervous system development cell differentiation rhythmic process
Process(es)
beta-amyloid binding signal transducer activity receptor activity transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity neurotrophin TRKA receptor binding protein binding Rab GTPase binding ubiquitin protein ligase binding nerve growth factor binding preprotein binding death receptor activity neurotrophin binding
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