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Invitrogen
NIBP Polyclonal Antibody
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产品信息
PA5-23130
产品规格
种属反应
Bovine,
Dog,
Chicken,
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids in a range between 30-80 of mouse TLR4.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum with 50% glycerol
内含物
0.025% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence homology: 100% homologous in human (isoform CRA_A and CRA_b), chimpanzee, monkey, mouse, opossum, rat and dog; xenopus (94%).
Confocal immunofluorescence: Cells were fixed with 4% paraformaldehyde in PBS for 10 min and then permeabilized with 0.5 % Triton X-100 for 20 min at room temperature (RT). The cells were blocked with PBS containing 10 % BSA and probed with NIBP pAB for 1 hour at RT. After washing with PBS, cells were incubated with Alexa conjugated goat anti-mouse antibodies.
靶标信息
NIBP is a 1246 amino acid intracellular regulatory protein. Reports suggest that NIBP physically interacts with NIK, IKK (beta), but not IKK (alpha) or IKK (gamma) and thus acts as a novel enhancer of cytokine-induced NF-(kappa) B signaling pathway. Due to its neuronal expression NIBP is considered as a potential target for modulating the NF-(kappa) B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway. NIBP is mainly expressed in brain, muscle, heart, and kidney.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IKK2 binding protein; NIK and IKK(beta) binding protein; NIK and IKK-beta binding protein; NIK and IKK{beta} binding protein; NIK- and IKBKB-binding protein; Trafficking protein particle complex subunit 9; TRAPP 120 kDa subunit; Tularik gene 1 protein
基因别名: 1810044A24Rik; 2900005P22Rik; 4632408O18Rik; IBP; IKBKBBP; KIAA1882; mKIAA1882; MRT13; NIBP; T1; TRAPPC9; TRS120; TRS130
UniProt ID: (Human) Q96Q05, (Bovine) Q32PH0, (Mouse) Q3U0M1
Entrez Gene ID: (Dog) 482058, (Chicken) 420312, (Human) 83696, (Bovine) 533451, (Mouse) 76510
