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Proteintech
NIFK Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-12615
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NIFK fusion protein Ag3284
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: SGPAGPILS LNPQEDVEFQ KEVAQVRKRI TQRKKQEQLT PGVVYVRHLP NLLDETQIFS YFSQFGTVTR FRLSRSKRTG NSKGYAFVEF ESEDVAKIVA ETMNNYLFGE RLLECHFMPP EKVHKELFKD WNIPFKQPSY QSVKRYNRNR TLTQKLRMEE RFKKKERLLR KKLAKKGIDY DFPSLILQKT ESISKTNRQT STKGQVLRKK KKKVSGTLDT PEKTVDSQGP TPVCTPTFLE RRKSQVAELN DDDKDDEIVF KQPISCVKEE IQETQTPTHS RKKRRRSSNQ
靶标信息
NIFK, also known as nucleolar protein interacting with the forkhead homolog protein, is a gene associated with several cancer types and is considered a potential prognostic biomarker. This gene functions within the nucleolus and plays a critical role in cellular proliferation, metastasis, and invasiveness, particularly noted in hepatocellular carcinoma (HCC) and colorectal cancer. NIFK expression is regulated via several pathways, including the MYC proto-oncogene pathway, and its silencing can lead to decreased fatty acid synthesis in colorectal cancer cells. Furthermore, it's involved in the regulation of innate immunity through pathways such as NF-kB in specific cancer cells. Due to its involvement in cancer progression, NIFK is being explored as a therapeutic target and holds promise for advancing precision medicine strategies across various cancer treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hNIFK; Ki67ip; MKI67 (FHA domain) interacting nucleolar phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI-67
基因别名: MKI67IP; NIFK; NOPP34
UniProt ID: (Human) Q9BYG3
Entrez Gene ID: (Human) 84365
