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Proteintech
NKCC2 Polyclonal Antibody
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产品信息
13636-1-AP
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NKCC2 fusion protein Ag4564
偶联物
形式
Liquid
浓度
0.24 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MSLNNSSNVF LDSVPSNTNR FQVSVINENH ESSAAADDNT DPPHYEETSF GDEAQKRLRI SFRPGNQECY DNFLQSGETA KTDASFHAYD SHTNTYYLQT FGHNTMDAVP KIEYYRNTGS ISGPKVNRPS LLEIHEQLAK NVAVTPSSAD RVANGDGIPG DEQAENKEDD QAGVVK
靶标信息
The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BSC1; bumetanide-sensitive cotransporter type 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter; MGC48843; mNKCC2; Na-K-2Cl cotransporter 2; Solute carrier family 12 member 1
基因别名: AI788571; D630042G03Rik; mBSC1; Nkcc2; Slc12a1; urehr3
UniProt ID: (Mouse) P55014
Entrez Gene ID: (Mouse) 20495
kidney development
transport
ion transport
potassium ion transport
sodium ion transport
chloride transport
excretion
protein insertion into membrane from inner side
ion transmembrane transport
renal rubidium ion absorption
chemical homeostasis
transmembrane transport
positive regulation of calcineurin-NFAT signaling cascade
cellular hyperosmotic salinity response
cation transmembrane transport
chloride transmembrane transport
