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NeoBiotechnologies
NKX3.1 Monoclonal Antibody (NKX3.1, 2836)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
4824-MSM6-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
NKX3.1, 2836
抗原
Recombinant fragment (around aa 92-224) of human NKX3.1 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is tested in direct ELISA.
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeobox protein NK-3 homolog A; NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag
基因别名: BAPX2; NKX3; NKX3.1; NKX3A
UniProt ID: (Human) Q99801
Entrez Gene ID: (Human) 4824
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
MADS box domain binding
DNA-binding transcription factor binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
metanephros development
somitogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
salivary gland development
heart development
positive regulation of cell proliferation
male gonad development
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
androgen receptor signaling pathway
prostate gland development
regulation of protein localization
response to testosterone
response to lipid
dorsal aorta development
regulation of cell proliferation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
negative regulation of epithelial cell proliferation
regulation of multicellular organismal process
positive regulation of cell division
positive regulation of protein kinase B signaling
pharyngeal system development
branching involved in prostate gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to steroid hormone stimulus
cellular response to hypoxia
cellular response to xenobiotic stimulus
positive regulation of androgen secretion
positive regulation of intrinsic apoptotic signaling pathway
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