Bioss

NLGN1/NLGN2 Polyclonal Antibody

问题与答案

问题与答案

问题与答案

抗体检测数据 (2)

NLGN1/NLGN2 Antibody in Flow Cytometry (Flow)

NLGN1/NLGN2 Antibody in Flow Cytometry (Flow)

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NLGN1/NLGN2 Antibody (BS-11098R) in Flow

U251 cells probed with NLGN1/NLGN2 Polyclonal Antibody, unconjugated (bs-11098R) at 1:100 dilution for 30 minutes compared to control cells (dark blue), secondary only (light blue) and isotype control (orange).

NLGN1/NLGN2 Antibody in Flow Cytometry (Flow)

NLGN1/NLGN2 Antibody in ELISA (ELISA)

Product Image Gallery

NLGN1/NLGN2 Antibody in Flow Cytometry (Flow) — U251 cells probed with NLGN1/NLGN2 Polyclonal Antibody, unconjugated (bs-11098R) at 1:100 dilution for 30 minutes compared to control cells (dark blue), secondary only (light blue) and isotype control (orange).

NLGN1/NLGN2 Antibody in ELISA (ELISA) — Antigen: bs-11098P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1:5000; TMB staining; Read the data in Microplate Reader by 450nm.

产品信息

BS-11098R

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:500

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:100-1:500

-

流式细胞分析 (Flow)

1:100

-

酶联免疫吸附实验 (ELISA)

1:5,000-1:10,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human NLGN2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Neuroligin I; Neuroligin-1; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2

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基因别名: 6330415N05Rik; BB179718; KIAA1070; KIAA1366; mKIAA1070; NL1; NL2; Nlg1; NLGN1; NLGN2

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UniProt ID: (Human) Q8N2Q7, (Human) Q8NFZ4, (Mouse) Q99K10, (Rat) Q62765, (Rat) Q62888, (Mouse) Q69ZK9

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Entrez Gene ID: (Human) 22871, (Human) 57555, (Mouse) 192167, (Rat) 116647, (Rat) 117096, (Mouse) 216856

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receptor activity PDZ domain binding neurexin family protein binding protein dimerization activity cell adhesion molecule binding carboxylic ester hydrolase activity scaffold protein binding protein binding cell adhesion molecule

regulation of respiratory gaseous exchange by neurological system process protein targeting heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion nervous system development synapse assembly positive regulation of circadian sleep/wake cycle, wakefulness synaptic vesicle targeting calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules neuronal signal transduction neuron projection development positive regulation of synaptic transmission, GABAergic protein localization to synapse establishment of protein localization regulation of neuron differentiation rhythmic process cytoskeletal matrix organization at active zone protein homooligomerization protein heterotetramerization positive regulation of filopodium assembly positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis terminal button organization synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering neurexin clustering involved in presynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse positive regulation of ruffle assembly positive regulation of synaptic vesicle endocytosis positive regulation of protein localization to synapse positive regulation of intracellular signal transduction positive regulation of synaptic vesicle exocytosis regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering single organismal cell-cell adhesion sensory perception of pain positive regulation of insulin secretion locomotory exploration behavior cell-cell junction maintenance modulation of synaptic transmission synapse organization neuromuscular process controlling balance gephyrin clustering involved in postsynaptic density assembly positive regulation of inhibitory postsynaptic potential cell adhesion synaptic vesicle transport inhibitory postsynaptic potential metabolic process neuronal ion channel clustering thigmotaxis jump response social behavior positive regulation of cell proliferation insulin metabolic process positive regulation of t-SNARE clustering