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Proteintech
NLRP6 Polyclonal Antibody
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产品信息
30973-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NLRP6 fusion protein Ag34516
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MDQPEAPCSS TGPRLAVARE LLLAALEELS QEQLKRFRHK LRDVGPDGRS IPWGRLERAD AVDLAEQLAQ FYGPEPALEV ARKTLKRADA RDVAAQLQER RLQRLGLGSG TLLSVSEYKK KYREHVLQLH ARVKERNARS VKITKRFTKL LIAPESAAPE EAMGPAEEPE PGRARRSDTH TFNRLFRRDE EGRRPLTVVL
靶标信息
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin II/vasopressin receptor; angiotensin/vasopressin receptor; dual angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NACHT/LRR/pyrin domain-containing protein 6; NLR family, pyrin domain containing 6; Non-angiotensin-vasopressin receptor; Non-AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYRIN-containing APAF1-like protein 5; PYRIN-containing APAF1-like protein 5-like
基因别名: AI504961; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044, (Mouse) Q8K0L4, (Rat) Q63035
Entrez Gene ID: (Human) 171389, (Mouse) 101613, (Rat) 171390
G-protein coupled receptor signaling pathway
response to bacterium
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
regulation of inflammatory response
negative regulation of immune response
regulation of mucus secretion
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
innate immune response
negative regulation of ERK1 and ERK2 cascade
