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Invitrogen
NLRP6 Polyclonal Antibody
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NLRP6 Antibody (PA5-110033) in WB
Western blot analysis of NLRP6 in various lysates. Samples were incubated with NLRP6 Polyclonal antibody (Product # PA5-110033) using a dilution of 1:400, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110033
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-110 of human NLRP6 (NP_6122022)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.39 mg/mL
规格
39 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MDQPEAPCSS TGPRLAVARE LLLAALEELS QEQLKRFRHK LRDVGPDGRS IPWGRLERAD AVDLAEQLAQ FYGPEPALEV ARKTLKRADA RDVAAQLQER RLQRLGLGSG
靶标信息
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin II/vasopressin receptor; angiotensin/vasopressin receptor; dual angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NACHT/LRR/pyrin domain-containing protein 6; Non-angiotensin-vasopressin receptor; Non-AVR; PYRIN-containing APAF1-like protein 5; PYRIN-containing APAF1-like protein 5-like
基因别名: AI504961; Avr; NALP6; Navr; Navr/Avr; NLRP6; PYPAF5
UniProt ID: (Mouse) Q91WS2, (Rat) Q63035
Entrez Gene ID: (Mouse) 101613, (Rat) 171390
G-protein coupled receptor signaling pathway
response to bacterium
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
regulation of inflammatory response
negative regulation of immune response
regulation of mucus secretion
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