Invitrogen

NMDAR1 Polyclonal Antibody

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NMDAR1 Antibody in Western Blot (WB) — Western blot analysis of NMDAR1 in 10 mg of HEK 293 cells using a Polyclonal antibody (Product # PA5-95644). Specific immunolabeling of the ~120kDa NR1 subunit of the NMDA receptor containing the C2' splice variant insert (3 and 4). 1) No NR1 expression; 2) NR1 subunit containing only the C2 Insert; 3) NR1 subunit containing the C1 and C2' Insert; 4) NR1 subunit containing the N1 and C2' Insert.

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

Assay-Dependent

-

免疫组化 (IHC)

Assay-Dependent

-

产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2' splice variant insert conjugated to KLH

偶联物

Unconjugated

形式

Lyophilized

纯化类型

Antigen Affinity Chromatography

保存液

5mM Ammonium bicarbonate

内含物

no preservative

保存条件

-20°C

RRID

AB_2807446

靶标信息

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: GluN1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1

基因别名: GluN1; GluRdelta1; Glurz1; GluRzeta1; Grin1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174

UniProt ID: (Rat) P35439, (Mouse) P35438

Entrez Gene ID: (Rat) 24408, (Mouse) 14810

分子生物学功能: transmembrane signal receptor

conditioned taste aversion startle response suckling behavior response to amphetamine cation transport calcium ion transport cellular calcium ion homeostasis respiratory gaseous exchange learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning visual learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine propylene metabolic process sensory perception of pain pons maturation cerebral cortex development ion transmembrane transport regulation of ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis neuromuscular process protein tetramerization response to calcium ion regulation of synapse assembly calcium ion homeostasis excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide calcium ion transmembrane transport cellular response to manganese ion positive regulation of excitatory postsynaptic potential transport ion transport chemical synaptic transmission cation transmembrane transport

参与通路

ionotropic glutamate receptor activity NMDA glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity cation channel activity calcium channel activity calcium ion binding protein binding calmodulin binding glycine binding glutamate binding enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity receptor activity ion channel activity